Fast Preparation of Peptide Tools to address new emerging Viruses: Case example SARS-CoV-2

Abstract The emergence of new virus species or variants poses a major challenge for healthcare systems. Countermeasures, including vaccine development, need to be developed without delay ensure success. Vaccine and antibody development depend on highly efficient tools antigen discovery, epitope mapping, diagnostics (clinical) immune monitoring. Here we present workflow peptide tool that can rapidly adapted emerging viruses. It combines bioinformatics algorithms an ultra-high throughput synthesis method alongside high-content assay formats. Data from different SARS-CoV-2 studies are presented addressing elucidation both cellular humoral responses. Robust spike-specific responses were measured using Spike PepMix ™peptide pools during infection and/or response monitoring [ 1]. Using mapping (matrix) immunodominant T-cell was identified may contribute the optimization existing vaccines 2]. In addition, Covid-19 convalescents against all proteins analyzed Humoral analysis by high-density microarrays B cell epitopes as starting points alternative diagnostic tests 3]. conclusion, show readily available tailored formats, exemplified SARS-CoV-2, important fast viruses concern.